Immunometabolism and Innate Immune Variability

Innate immune responses are strongly influenced by cellular metabolism and bioenergetic state. Changes in glycolysis, mitochondrial activity, and nutrient utilisation can fundamentally alter how immune cells respond to stimulation. Our research investigates how metabolic and bioenergetic pathways shape innate immune function and contribute to interindividual variability in immune responses. These metabolic programmes determine immune cell activation, cytokine production, and inflammatory potential, linking cellular energy metabolism directly to immune regulation.

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We study how metabolic state, disease context, and environmental exposures influence innate immune behaviour to understand why individuals respond differently to infection, vaccines, or complex therapeutics.

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Key areas include:
Immunometabolism of innate immune cells
Bioenergetic control of inflammatory signalling
Metabolic drivers of trained immunity
Inter-individual variability in immune responses
Metabolic influences on therapeutic safety and efficacy

Keywords: innate immunity, immune metabolism, microenvironment, transporters