IMMUNOCOMPATIBILITY GROUP
Director and PI
Professor Neill Liptrott, Chair in Pharmacology and Immunocompatibility
Our research aims to understand the concepts and mechanisms which underly the interface between novel therpaies and the immune system; to support their translation to clinical use and gain insight into the fundamental biology behind them. We use advanced techniques and technologies to explore and investigate these areas of research which is supported, generously, by funding from a number of sources
Why immunocompatibility and not immunotoxicity?
Immunotoxicity focuses on harmful effects on the immune system. Immunocompatibility asks a broader question: how does a medicine or material interact with the immune system, and is that interaction appropriate for its intended use and patient? It considers safety alongside efficacy, tolerability, formulation, route of administration, and individual immune variability. This allows immune responses to be predicted, measured and, where beneficial, modified.
RESEARCH AREAS
An overview of current, main, research areas is below. Click on the links to find out more!
IMMUNOMAETABOLISM AND INNATE IMMUNE VARIABILITY
Understanding how immune cells sense, an utilise, nutrients in their environment is key to predicting how they are likely to responde to exogenous materials. Here, we are exploring metabolic profiles of immune cells in various physiologically relevant models.