Director & PI - Dr Neill Liptrott
Our research aims to understand the concepts and mechanisms which underly the interface between novel therpaies and the immune system; to support their translation to clinical use and gain insight into the fundamental biology behind them. We use advanced techniques and technologies to explore and investigate these areas of research which is supported, generously, by funding from a number of sources.
An overview of current, main, research areas is below. Click on the links to find out more!
ENGINEERED NANOMATERIALS: ASSESSING THEIR BIOCOMPATIBILITY AND TOXICITY.
Linking the physical, and chemical, characteristics of advanced materials to their biological effects.
IMPACT OF IMMUNE STATUS ON NANOMATERIAL BIOCOMPATIBILITY, DRUG DISPOSITION AND INTRACELLULAR PHARMACOLOGY
We have previously shown that immune signalling, which may differ between healthy and disease states, may impact on the intracellular dispostion of therapies. This work aims to explore those mechanisms and define possible implications for therapies.
INFLUENCE OF METABOLIC PROFILE, NUTRIENT SENSING AND EXOGENOUS FACTORS ON IMMUNE RESPONSES TO XENOBIOTICS AND EXOGENOUS MATERIALS
Understanding how immune cells sense, an utilise, nutrients in their environment is key to predicting how they are likely to responde to exogenous materials. Here, we are exploring metabolic profiles of immune cells in various physiologically relevant models.